Neonatal Brain Monitoring

COURSE INFO

Conference Purpose Statement

Call for Abstracts

Target Audience

Exhibitor Prospectus

Objectives

Accreditation

Pre-conference Workshops

Program Agenda

Faculty

Course Evaluation and Outcomes Measurement

Faculty Disclosure

Registration

Location

Accommodations for Disabilities

The 5th International Conference on Brain Monitoring and Neuroprotection in the Newborn

January 21-23, 2010
Sheraton Sand Key Resort
Clearwater Beach, Florida

Sponsored by:

Click here to download the PDF brochure

Conference Purpose Statement

The International Conference on Brain Monitoring and Neuroprotection in the Newborn is intended to bring the most current and important research in these fields to a forum where the results can be translated for use by clinicians. Brain monitoring, for the purposes of this conference, is defined as those methods used on a continuous or repetitive basis to assess brain function in the newborn such as continuous EEG or near-infrared spectroscopy. Neuroprotection, for the purposes of this conference, is defined as therapeutic hypothermia as well as any adjunctive measures that may be utilized along with it.

While these definitions are somewhat restrictive and will be stretched from time to time to include subjects of compelling interest, we think it is important to maintain a focus on these two closely-related and clinically-evolving areas. Broader neonatal neurology topics are available elsewhere (e.g., PAS/SPR, ESPR, the Hershey meeting, the Washington University conference), and a broadening of our scope would inevitably lead to a dilution of our focus. The raison d'etre of this meeting lies in the fact that neither researchers nor clinicians interested in learning the state of the art can find the whole of either field discussed consistently in any other place and to do so seems crucial to us at a time when both fields are growing rapidly in both the research and clinical arenas.

The conference is designed so that researchers and clinicians can, by attending at least every other year, derive a solid sense of the state of the art. In building bridges between research and clinical applications, it is vital that the foundations on either side of the bridge are clearly understood. This conference is intended to both describe and strengthen those foundations, as well as provide an international bridge between them.

Target Audience

This activity is designed to meet the educational needs of neonatologists, neurophysiologists, pediatric neurologists, NICU nurses, neonatal nurse practitioners, and any other clinician or researcher interested in learning about the cutting-edge field of neonatal brain monitoring.

Exhibitor Prospectus

Click here to download the exhibitor prospectus.

Objectives

Upon completion of this CME activity, attendees should be able to:

Explain the electrophysiologic basis for continuous EEG monitoring of the newborn;
Analyze advantages and shortcomings of continuous single-lead EEG monitoring;
Differentiate the pros and cons of continuous EEG monitoring in high-risk premature and term newborns;
Explain the underlying principles for current strategies to protect the newborn brain from injury;
Analyze other techniques for monitoring neonatal brain function, such as near infrared spectroscopy, which are available or in the process of clinical development;
Determine how caregiving practices impact brain function;
Apply concepts and new applications in their own NICU;
Contrast the relative benefits and disadvantages of providing therapeutic hypothermia using head or total body cooling
Implement important supportive measures for infants receiving therapeutic hypothermia;
Describe possible mechanisms for brain injury caused by seizure activity;
Identify promising targets for anti-epileptic drugs in infants;
Describe new concepts for the practice of management of seizures in infants after discharge from the NICU;
Discuss the role of neuroimaging in evaluation of high risk infants;

Accreditation

Attendees should claim only those credits that they actually spent in the educational activity.

Physicians: USF Health is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

USF Health designates this educational activity for a maximum of 17.75 AMA PRA Category 1 Credits™ (including pre-conference workshops). Physicians should only claim credit commensurate with the extent of their participation in the activity.

Nurses: The University of South Florida College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation. This activity is for up to 17.75 contact hours (including pre-conference workshops).

Pre-conference Workshops: Thursday, January 21, 2010

WORKSHOP A: Establishing/Enhancing a Therapeutic Hypothermia Program
John Barks will discuss practical consideration in establishing a neonatal hypothermia program. Considerations include determining whether to start a program, personnel, choice of method(s), cooling during transport, equipment and supplies, training, parent and referring hospital communication, systemic complications, neuro-developmental follow-up, and future directions.
Chris Adams will discuss challenges that exist in operating an effective hypothermia program. These challenges include staff education, maintenance and storage of necessary supplies, and the efficiency required to apply hypothermia. Suggestions for solutions will be provided.

Upon completion of this workshop, participants should be able to:

Describe the evidence supporting the benefits and safety of cooling for neonates with HIE.
Evaluate institutional or regional needs for cooling, based on patient data.
Identify the resources needed to establish a cooling program: supplies, personnel, communication, training and expertise.
Interpret clinical situations in which to apply hypothermia and when it is not warranted.
Analyze challenges to implementation of an effective hypothermia program
Develop strategies to overcome the challenges in the maintenance of a hypothermia program.

WORKSHOP B: Establishing a Clinical NIRS Program.
Learning Objectives
Upon completion of this workshop, participants should be able to:

Explain globally the scientific basis of neonatal NIRS monitoring of cerebral oxygenation (regional cerebral oxygen saturation [rScO2] or tissue oxygen index [TOI]).
Evaluate a NIRS tracing of rScO2/TOI, including identification of artefacts.
Discuss the efficacy of NIRS (rScO2/TOI) for early prediction of complications such as patent ductus arteriosus, outcome of severe asphyxia etc.
Discuss the clinical utility of recording NIRS with other physiological trends of aEEG/EEG, blood pressure, arterial oxygen saturation.

Note: This workshop does not require that participants have previous knowledge about the basic principles of, or have experience with, near infrared spectroscopy (NIRS) clinical and/or research with this method

WORKSHOP C: aEEG for New Users
This workshop is designed for clinicians who are considering obtaining continuous EEG equipment or who have less than one year of experience working with aEEG. The following topics will be discussed in this 3 hour workshop; they are not in any particular order. (There is a 30 minute break mid-way through the workshop.)

Importance of continuous EEG brain monitoring
Advantages and disadvantages of neurophysiological monitoring with EEG
Predictability of aEEG
Pitfalls and artifacts of aEEG
Tips for applying electrodes
Indications for using aEEG
Bedside care provider responsibilities
Communication with parents
Therapeutic time window
Sample traces
Case presentations
Importance of accurately recognizing and appropriately treating seizures

WORKSHOP D: aEEG for Experienced Users
A series of unusual but important tracings will be presented in the first workshop segment. In the second segment, participants are invited to submit interesting or challenging tracings of their own for discussion. (Hard copy of the tracings with relevant clinical history must be submitted by December 21, 2009 so that sufficient copies can be made for all participants. Submit hard copies to Bobbi Rose. E-mail her at brose@health.usf.edu for more information.)

Learning Objectives
Upon completion of this workshop, participants should be able to:

Explain the scientific basis of neonatal aEEG/EEG-monitoring.
Apply aEEG/EEG-monitoring and analyse recordings in high-risk infants in the NICU, including identification of artefacts.
Review the efficacy of aEEG/EEG for early prediction of outcome and for identification of seizures.
Appraise the clinical utility of recording other physiological trends together with aEEG/EEG, e.g. NIRS, blood pressure, oxygen saturation.
Discuss how aEEG/EEG can be applied and analyzed for scientific purposes.

Note: This workshop requires that participants have previous knowledge about basic aEEG/EEG principles, and experience (clinical and/or research) of aEEG/EEG monitoring.

Program Agenda

Thursday, January 21, 2010
TIME	SESSION / EVENT
7:30 am – 8:30 am	Registration & Continental Breakfast
8:30 am – 12:00 pm	Concurrent Sessions
	Workshop A: Establishing / Enhancing a Therapeutic Hypothermia Program (John Barks, MD and Chris Adams, RN)
	Workshop B: Establishing a Clinical NIRS Program (Frank van Bel, MD, Gunnar Naulaers, MD, and Petra Lemmers, MD)
12:00 pm – 1:30 pm	Lunch on own
1:30 pm – 5:00 pm	Concurrent Sessions
	Workshop C: aEEG for New Users (Jan Paisley, MD)
	Workshop D: aEEG for Experienced Users (Mona Toet, MD, PhD & Lena Hellstrom-Westas, MD)
7:00 pm – 9:00 pm	Poster Walk & Exhibit Hall Reception
Friday, January 22, 2010
7:30 am – 8:30 am	Registration & Continental Breakfast
8:30 am – 8:40 am	Welcome (Bob White, MD)
8:40 am – 9:20 am	Effects of Clinical Interventions on Brain Function (Mark Scher, MD)
9:20 am – 10:00 am	Basic Science of Neuroprotection (Michael Weiss, MD)
10:00 am – 10:25 am	Break
10:25 am – 11:05 am	Report on VON HIE Registry (Robert Pfister, MD)
11:05 am – 11:30 am	Status of Therapeutic Hypothermia 2010 (John Barks, MD)
11:45 pm – 12:00 pm	ARS (John Hartline, MD, FAAP)
12:00 pm – 1:05 pm	Lunch (provided)
1:05 pm – 1:35 pm	Current Clinical Applications for NIRS (Frank van Bel, MD)
1:35 pm – 2:35 pm	Abstract Session Quantitative Analysis for Classifying Neonatal EEG in HIE (Irina Korotchikova, MD) aEEG Evolution During Therapeutic Hypothermia and Prediction of NICU Outcome in Encephalopathic Neonates (An Massaro, MD) Can Characteristics of the Amplitude Integrated EEG Help Determine the Length of Hospitalizations for Late Preterm Infants? (Ross Sommers, MD) Higher Levels of Arterial Carbon Dioxide are Associated with Suppression of EEG in the Extremely Preterm Infant (Sverre Wikstrom, MD)
2:35 pm – 3:05 pm	Role of Neuroimaging in Evaluation of Brain Development and Injury (Amit Mathur, MD)
3:05 pm – 4:00 pm	Break & Poster Presentations Effect of General Anesthesia on Children’s aEEG and Spectral Edge Frequency (Stephen McKeever, RGN, RN, Dip. Trop. Nurse) Prediction of Outcome with Early Amplitude Integrated EEG in Very Low Birth Weight Infants Managed with Early Nasal Continuous Positive Airway Pressure (Mohamed El-Dib, MD) Absent ‘Cyclic Change’ on aEEG for Detecting Periventricular Leukomalacia (Naoko Hayashi, MD) EEG Confirmed Seizures in Infants with Neonatal Encephalopathy Treated with Whole-Body Hypothermia (Taeun Chang, MD) Placental Pathology in Infants with Neonatal Encephalopathy Presenting for Therapeutic Hypothermia (Taeun Chang, MD) Magnetic Resonance Thermal Imaging (William Walsh, MD)
4:00 pm – 5:15 pm	Breakout Sessions
	A: Neurological Evaluation of the Newborn (Lenora Lehwald, MD)
	B: aEEG vs. cEEG (Bob Clancy, MD & Eilon Shany, MD)
	C: Clinical Research Brainstorming (Sampsa Vanhatalo, MD, PhD)
	D: ACNS Consensus Statements & Guidelines on Neonatal EEG Monitoring (Taeun Chang, MD)
	E:Cooling Issues for the Bedside Caregiver (Moderators: Chris Adams, RN & Sue VanderWaal, RNC, MSN) Feasibility of Hydrogel Electrodes for aEEG Monitoring on Preterm Infants at Bedside (Shuyuaan Foreman, PhD) “Keep Baby Cool” Concept: Therapeutic Hypothermia After Perinatal Asphyxia – Nursing Protocol (Beatrix Wiebe, MD) Experience with Hypothermia Application Outside of the Tertiary NICU by a Nurse-based Neonatal Transport Team (Marion Molesky, MSN)
5:15 pm	Adjourn for the day
Saturday, January 23, 2010
7:30 am – 8:30 am	Registration & Breakfast Table Networking Neurologists / neurophysiologists (Bob Clancy, MD) Nurses (Chris Adams, RN, Sue Vanderwaal, RNC, MSN) Therapeutic Hypothermia (Alistair Gunn, MD, PhD) aEEG (Eilon Shany, MD) NIRS (Frank van Bel, MD) Clinical Research Brainstorming (Sampsa Vanhatalo, MD, PhD)
8:30 am – 8:35 am	Welcome (John Barks, MD)
8:35 am – 9:05 am	Ontogeny of Brain Activity (Sampsa Vanhatalo, MD, PhD)
9:05 am – 9:35 am	Neurophysiology of Seizures (Alistair Gunn, MD, PhD)
9:35 am – 10:05 am	Seizure Detection (Geraldine Boylan, MD)
10:05 am – 11:00 am	Break
10:20 am – 11:00 am	Poster presentations Real-time Monitoring of Cerebral Auto-regulation in Premature Infants (Willa Drummond, MD, MS) Neonatal Cerebral Oximetry Monitoring in Preterm Infants with RDS (Nickie Niforatos, MD) Stable Intensive Care Nursery Infants’ Cerebral Oxygenation in Supine versus Prone Position (Heather Mann, RN, MSN, NNP-BS, CNS) The Relationship between Cerebral Oxygenation and Mean Arterial Blood Pressure in Sick Preterm Infants (Daithi de Baroid) Automated Neonatal Seizure Detection Using Machine Learning (Nathan Stevenson, PhD)
11:00 am – 11:30 am	Pharmacotherapy of Seizures (Bob Clancy, MD)
11:30 am – 12:00 pm	Abstract Session Clinical Seizures Prior to Hypothermia do not Predict Subsequent Electrographic Seizures in Term Newborns with Neonatal Encephalopathy (Sonia Lomeli Bonifacio, MD) Seizure Detection by Amplitude Integrated and Conventional EEG (Eilon Shany, MD)
12:00 pm – 1:00 pm	Lunch (box lunches provided)
1:00 pm – 1:30 pm	Post-discharge Management of the Newborn with Seizures (Ronnie Guillet, MD, PhD)
1:30 pm – 2:00 pm	Audience Response Session (John Hartline, MD, FAAP)
2:00 pm - 2:30 pm	Break & Poster Presentations
2:30 pm – 4:15 pm	Roundtable: Controversies in Management of Neonatal Seizures (Bob Clancy, MD, Alistair Gunn, MD, PhD, Lena Hellstrom-Westas, MD, Mona Toet, MD, PhD, and Sampsa Vanhatalo, MD, PhD)
4:15 pm – 4:45 pm	What Have We Learned?
4:45 pm – 5:00 pm	Wrap-Up (Bob White, MD)
5:00 pm	Adjourn until 2011 in Amsterdam!

Faculty

Course Co-Chairs
Robert White, MD Regional Newborn Program Memorial Hospital of South Bend South Bend, IN USA	Linda de Vries, MD Professor in Neonatal Neurology University Medical Centre Wilhelmina Children’s Hospital Utrecht, The Netherlands

Lena Hellstrom-Westas, MD Associate Professor Department of Paediatrics Uppsala University Uppsala, Sweden	Marianne Thoresen, MD, PhD Professor of Neonatal Neuroscience University of Bristol; Dept. of Child Health St. Michaels Hospital Bristol, United Kingdom

Mona Toet, MD, PhD Department of Neonatology University Medical Centre Wilhelmina Children’s Hospital Utrecht, The Netherlands	Frank van Bel, MD Professor of Neonatology University Medical Centre Wilhelmina Children’s Hospital Utrecht, The Netherlands
Invited Faculty
Chris Adams University of Michigan Ann Arbor, Michigan	Amit Mathur, MD Associate Professor of Pediatrics Division of Newborn Medicine Associate Medical Director, NICU St. Louis Children’s Hospital St. Louis, Missouri

John Barks, MD Associate Professor of Pediatrics Director, Neonatal-Perinatal Research Programs University of Michigan Ann Arbor, Michigan	Gunnar Naulaers, MD, PhD Professor of Neonatology Neonatal Intensive Care Unit Department of Woman and Child University Hospitals Leuven Leuven, Belgium

Geraldine Boylan, PhD Senior Lecturer in Paediatrics Department of Paediatrics & Child Health University College Cork Cork, Ireland	Jan Paisley, MD Medical Director, NICU Poudre Valley Hospital Ft. Collins, Colorado

Taeun Chang, MD Director, Neonatal Neurology Program Children’s National Medical Center Washington, DC	Robert Pfister, MD Neonatologist University of Vermont Burlington, Vermont

Robert R. Clancy, MD Professor of Neurology and Pediatrics University of Pennsylvania School of Medicine Philadelphia, Pennsylvania	Mark Scher, MD Professor of Pediatric Neurology Director, Programs in Pediatric Epilepsy and Fetal / Neonatal Neurology Rainbow Babies & Children’s Hospital Cleveland, Ohio

Ronnie Guillet, MD, PhD Pediatric Specialist University of Rochester Rochester, New York	Eilon Shany, MD Neonatologist Soroka Medical Center Ben-Gurion University at the Negev Beer-Sheva, Israel

Alistair Gunn, MD, PhD Department of Physiology The University of Auckland Auckland, New Zealand	Mona Toet, MD, PhD Neonatologist University Medical Centre Wilhelmina Children’s Hospital Utrecht, The Netherlands

John Hartline, MD, FAAP Consultant Department of Education American Academy of Pediatrics Itasca, Illinois	Frank van Bel, MD Professor of Neonatology University Medical Centre Wilhelmina Children’s Hospital Utrecht, The Netherlands

Lena Hellstrom-Westas, MD Associate Professor Department of Paediatrics Uppsala University Uppsala, Sweden	Sampsa Vanhatalo, MD, PhD Department of Clinical Neurophysiology Hospital for Children and Adolescents University Hospital Helsinki, Finland

Lenora M. Lehwald, MD Associate Professor of Clinical Pediatrics Division of Child Neurology The Ohio State University College of Medicine Attending Neurologist Nationwide Children’s Hospital Columbus, Ohio	Michael Weiss, MD Division of Neonatology Department of Pediatrics University of Florida College of Medicine Gainesville, Florida

Petra Lemmers, MD Department of Neonatology Wilhelmina Children’s Hospital University Medical Centre Utrecht, The Netherlands

Course Evaluation and Outcomes Measurement

The evaluation process is a critical component in our strategy to offer excellence in our future conferences and to ensure we are addressing the educational needs of our audience. Your comments and feedback make a difference! Please complete the evaluation forms, which will be distributed on-site, and return them to either the session facilitator or the registration desk.

In addition, we measure the outcome of the education using a post-event survey sent via e-mail. The results of this survey are equally important as we need to know if the education made a difference, be it in awareness, practice change, health outcomes, or all the above. Please complete the survey when it comes to your in-box approximately 6 weeks after the conclusion of the conference.

Faculty Disclosure

USF Health adheres to the ACCME Standards regarding commercial support of continuing medical education. It is the policy of the USF Health that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflicts of interest are resolved, and also that speakers will disclose any unlabeled/unapproved use of drugs or devices during their presentation. Detailed disclosure will be made in the course syllabus.

Registration

Event	Early Bird (through 12/31/09)	Regular (after 12/31/09)
Pre-Conference Workshops
A. Therapeutic Hypothermia	$200	$250
B. Establishing a Clinical NIRS	$200	$250
C. aEEG for New Users	$200	$250
D. aEEG for Experienced Users	$200	$250
Main Conference	$525	$575
Single Day (pick Friday or Saturday)	$300	$350

Conference Registration Fee Includes (per participant):

Workshop Fee: Attendance at the workshop, continuing education credit as applicable, handouts applicable to the workshop, refreshment breaks, poster walk, exhibit hall reception

Main Conference Fee: Attendance at the conference, continuing education credit as applicable, syllabus*, continental breakfast, refreshment breaks, lunch, poster walk, exhibit hall reception.
*The format of the syllabus has not been determined. It may be paper or CD with access to downloads in advance.

Online and fax registration is no longer available for this course, but you are welcome to register on-site at the Sheraton Sand Key Resort at the start of the program. Please download the registration form using the link below and bring your completed form and payment with you in order to register on-site. If you have any questions, please e-mail smakar@health.usf.edu

PRINTABLE ON-SITE REGISTRATION FORM

Cancellation notification must be in writing (fax or e-mail are acceptable) and received (not postmarked) by the close of business on December 31, 2009. A cancellation fee of $45 for workshops and $100 for main conference (total cancellation fee not to exceed $100) will be assessed. Cancellations received after December 31, 2009 will not receive a refund. No-shows will not receive a refund. However, substitutions are welcome. Please allow up to 3 weeks to receive the refund.

USF Health reserves the right to cancel this program due to unforeseen circumstances, in which case a full refund will be given to participants. USF Health will not be responsible for travel expenses incurred by the participant in the unlikely event that the program is cancelled.

Location

Sheraton Sand Key Resort
1160 Gulf Boulevard
Clearwater Beach, FL 33767
727-595-1611
website

Sink your toes into 10 acres of sugar-white sand at this exclusive beach resort located in Clearwater Beach, Florida. Enjoy pool and beach activities, tennis, spa services, fitness center, shopping, casual and fine dining, and more. You can also hop on a trolley to explore the scenic Clearwater Beach area.

A limited number of rooms have been reserved for this meeting at a special rate of $177 per night plus applicable sales tax. For reservations, call 727-595-1611 and identify yourself as a participant of the USF Brain Monitoring Conference to receive the special group rate. You may also reserve your room online by clicking HERE. The deadline to receive the group rate is December 19, 2009, so be sure to make your reservation early!

Dress: The planning committee encourages relaxed and comfortable dress throughout the conference; however, participants are encouraged to bring a sweater or a jacket to sessions as the temperature in meeting rooms often varies. Please know that Florida can get cold in January! The hotel is close to many theme parks and other attractions, so good walking shoes are recommended.

Airport & Ground Transportation: Both the Tampa International and Clearwater/St. Petersburg airports offer car rental. Direct van service is available via SuperShuttle for approximately $24 one-way or $44 round-trip (Tampa International), and can be secured at the airport. The phone number for SuperShuttle is 1-800-282-6817. Trips from the airport are “first-come, first-served.” Reservations are required for a return trip. Taxi fare from Tampa International to the Sheraton can exceed $60.
Tampa International Airport: www.TampaAirport.com
SuperShuttle: www.supershuttle.com

Equal Opportunity

Events, activities and facilities of the University of South Florida are available without regard to race, color, sex, national origin, disability, age, or Vietnam veteran status as provided by law and in accordance with the University's respect for personal dignity.

Accommodations for Disabilities

Please notify the office of Health Professions Conferencing Corp., 12901 Bruce B. Downs Blvd., MDC Box 60, Tampa, Florida, 33612 or call (813) 974-4296 a minimum of ten working days in advance of the event if a reasonable accommodation for a disability is needed.