Until approximately fourteen years ago, there was no approved disease modifying treatment for Multiple Sclerosis (MS). Since that time, the treatment options for patients have dramatically expanded. The sudden growth in effective agents in MS has stimulated the thought process on further improving the prognosis of the disease, including the prospects of neuroprotection and regeneration. The concept of “protective inflammation/ autoimmunity” has had profound consequences to the view of the pathogenesis and treatment of neuroinflammatory diseases, such as MS. It will also prove vital for neurodegenerative disorders, including Parkinson’s Disease (PD) and Alzheimer’s Disease (AD), in which inflammatory reactions occur.

Technological advances have the potential to radically alter the treatment of PD. Emerging biological approaches such as gene therapy are highly relevant to neurodegenerative disorders. Health care providers will be called upon to describe these approaches to their patients and determine who might benefit from them. In addition, there is continuing need to improve the use of existing medications for PD. Although there have been effective treatments for the symptoms of PD since the late 1960s, the controversy continues regarding the best way to use existing therapies and how to incorporate recently approved medications into a rational therapeutic approach. Two areas of greatest importance are the earlier diagnosis of individuals with mild Parkinsonian signs, and the management of patients with advanced PD who may have a complex “witches brew” of motor neuropsychiatric disturbances.

The University of South Florida College of Medicine adheres to the ACCME Standards regarding commercial support of continuing medical education. It is the policy of the USF College of Medicine that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved, and also that speakers will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made in the course syllabus.

This program is designed to meet the educational needs of neurologists and other health care providers that treat patients with neurodegenerative diseases.

• Assess the current views of pathogenesis of the progressive phases of MS and how this helps to analyze the relative roles of inflammatory and non-inflammatory processes in the disease
• Analyze how current and emerging MRI techniques can be used in MS patient management now and in the near future
• Translate recent advances in gene therapy and identify how this emerging technology may be applied to patients with PD in the future
• Improve accuracy of early diagnosis by identifying non-motor features of PD that may be present
• Determine appropriate initial treatment for PD and assess the short and longterm implications of different treatment choices for early PD
• Contrast the options for treatment of advancing motor features of PD
• Diagnose the spectrum of neuropsychiatric features that accompany later stage PD and determine appropriate therapy

The University of South Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The University of South Florida designates this educational activity for a maximum of 7 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Robert P. Lisak, MD, FAAN, FRCP
Parker Webber Chair in Neurology
Professor of Immunology & Microbiology
Department of Neurology
Wayne State University
Detroit, MI

Omar Khan, MD
Professor of Neurology
Director, Multiple Sclerosis Clinical Research Center
Wayne State University
Detroit, MI

Bruce Trapp, PhD
Professor and Chair
Department of Neuroscience
Cleveland Clinic Foundation, Lerner Research
The Ohio State University
Cleveland, OH

Lunch at French Laundry with wine pairing
Fee: $119 PP (OPTIONAL – there is limited availability for this activity)
The lunch at the French Laundry is full. However, you may be placed on a wait list. There is no charge to be on the wait list.

The French Laundry features award winning contemporary American cuisine with French influences. The Chef/Owner is Thomas A. Keller, who is widely regarded as one of America’s finest chefs. In 2001, Keller was named “America’s Best Chef” by Time Magazine and as “World Master of Culinary Arts” by a panel of international judges at the Wedgwood Awards. He and his restaurants have collected many accolades in the last decade including six awards from the James Beard Foundation: “Outstanding Chef: America,” “Outstanding Wine Service,” “Best Service.” Since 1999, the restaurant has received the Mobil Travel Guide’s Five Star Award.

Saturday Wine Tour & tasting at stag’s leap wine cellar (follows lunch)
Fee: $49 PP (OPTIONAL – there is limited availability for this activity

Since its founding in 1972 by Warren and Barbara Winiarski, Stag’s Leap’s winemaking aim has been to modify the natural richness and force characteristic of California grapes into wines noted for elegance and balance. The soil, microclimate and management of the winery’s selected vineyards yield wines distinguished by varietal excellence and unique regional characteristics. Stag’s Leap is best known for winning the famous blind tasting in Paris against the finest French wines. Their flagship wine, Cask 23, is world renowned.

You will arrive at Stag’s Leap Wine Cellars for a private tour and seated tasting of their Estate Wines paired with small bites. You will be welcomed outside at the Overlook with a glass of Sauvignon Blanc as you view their famous vineyards. From there you will enter the wine aging caves and tour on your way to the Great Room for their seated tasting. Chef Jonathan Bodner has created small bites to pair with Stag’s Leap Arcadia Chardonnay, SLV Cabernet Sauvignon, Fay Vineyards Cabernet Sauvignon and their remarkable Cask 23.

Saturday Bathhouse Dinner & One Treatment of your choice
Fee: $99 PP ($99 per additional treatment) Solage’s Mud Bar & Bathhouse (This is a Co-Ed Activity)

Mudslide: Enjoy the Mudslide experience at Spa Solage – a three-part circuit consisting of “The Mud,” “The Waters,” and “The Rest,” all part of a 100-year old Calistoga spa tradition. To begin, a talented “mud-tender” will offer a choice of mud cocktail - the mineral-enriched mud is blended with pure essential oils of your choice. Each mud cocktail is custom-designed to achieve specific results. After applying your special mud blend, rest in the private Mud Lounge or bake in the sun while your body is purified and re-mineralized. In the next step, “The Waters”, you’ll relax in one of the luxurious soaking tubs featuring Calistoga’s natural Geothermal spring waters. Your mudslide concludes in a state of the art sound chair, created to float you into a zerostress state of harmonic balance. The Mudslide may be enjoyed in private or as a group. Solage Massage (50 minutes): This firm and nurturing massage is customized according to your specific needs, designed to rejuvenate and relax you into oblivion.

You will have exclusive use of the Solage Bathhouse while enjoying a light dinner. There are limited couple rooms available. Space is limited.

Registration Fee: $149 • Guest Fee: $49 PP (Includes breakfast on Saturday & Sunday.)

Registration fee includes program syllabus, breakfast, and break on Saturday, breakfast & break on Sunday. It does not include the Saturday wine tour & lunch or the dinner activity. Upon receipt of your registration, a confirmation letter will be sent.

A refund (minus a processing fee of $25) will be given if written notice of cancellation is received on or prior to September 7, 2008. No refunds will be given for written cancellation requests received after September 7, 2008.

A refund (minus a processing fee of $25.00) will be given if written notice of cancellation is received on or prior to July 13, 2007. No refunds will be given for written cancellation requests received after July 13, 2007.

The University of South Florida College of Medicine reserves the right to cancel these seminars due to unforeseen circumstances. In the case of cancellation, a full refund will be given to participants. The USF COM will not be responsible for travel expenses incurred by the participant due to the seminar cancellation.

Solage Calistoga
755 Silverado Trail
Calistoga, CA 94515
Telephone: 866-942-7442
www.solagecalistoga.com

Solage Calistoga
Solage Calistoga is located in the California Wine Country with 89 studio style accommodations and countless ways to relax, refresh and enjoy. Solage takes the natural and makes it relaxing with organic design, thoughtful service and indulgent amenities. Everywhere you turn you will come across something unexpected. Take a cruiser bike for a spin through the beautiful 22 acres or into town. Energize yourself at the full service Spa Solage, take a dip in the pool with the Palisades mountains in the background or sit by the firepits after dark. Family friendly features at Solage include a children’s pool and play area. Dining is casual but refined with a full service ingredient driven restaurant and lounge.

Participants attending the USF MS/PD conference will receive a special discount rate of $299 per night (single/ double occupancy) plus applicable sales & resort tax (currently 12%). One room per registered participant only at this rate. This rate is for September 26th and 27th only. Reservations must be made by individual call-ins no later than August 26, 2008 in order to obtain this rate. After August 26, rooms will be subject to availability at prevailing rates. All attendees shall make reservations directly with the hotel, identifying themselves as members of “USF 5th Annual Neuroprotection: Defining a Clinical Strategy in Neurodegenerative Disease” group by calling 707-226-0818. A limited number of rooms have been reserved and will be assigned on a “first come first serve” basis. Check-in time is 3:00 PM, check-out time is 12:00 PM. You may check baggage at Guest Services Desk if arriving early or on departure date.

Please notify the CPD Office, 12901 Bruce B. Downs Blvd., MDC Box 60, Tampa, Florida, 33612 or call (813) 974-4296 a minimum of ten working days in advance of the event if a reasonable accommodation for a disability is needed.

Events, activities and facilities of the University of South Florida are available without regard to race, color, sex, national origin, disability, age, or Vietnam veteran status as provided by law and in accordance with the University's respect for personal dignity.