It has been realized in recent years that Multiple Sclerosis (MS) is not simply an inflammatory demyelinating disease, but also a degenerative disease with axonal and neuronal loss that eventually results in brain atrophy. While the early relapsing remitting phase of MS is considered primarily inflammatory and responds to immunomodulation, the later phase is primarily degenerative and is resistant to immunomodulatory intervention. Brain atrophy, as measured by advanced imaging techniques rather than inflammation, correlates with disability. Hence, there is considerable interest in understanding the molecular mechanisms that are responsible for neurodegeneration in MS, which could result in pharmacological intervention in the form of neuroprotective agents.

Although the target cell and mechanisms of neurodegeneration in MS and PD are different, it is possible that neuroprotective agents that affect the course of one disease may also have an effect on the other. Examples of such agents would be brain derived neurotrophic factor (BDNF), Glatiramer acetate specific T-cells, Minocycline, and Glutamate inhibitors.

As the population ages, the worldwide prevalence of Parkinson’s Disease (PD) is expected to increase substantially over the next several decades. While great strides have been made in controlling motor symptoms of PD, the underlying disease continues to progress with the emergence of several non-motor features like dementia. In addition, complex motor problems like gait freezing and balance problems become disabling. All patients with PD will eventually need to begin treatment for PD and there are different treatment options available. The choice of treatment can impact the evolution of PD features and overall quality of life. The findings from laboratory investigations and clinical trials will be reviewed to help guide decisions on initial treatment choices that can influence long term outcomes.

The goal of this course is to bring together experts in the areas of neurodegeneration, neuroprotection and imaging in MS and PD, in order to improve knowledge of these disabling disorders and how to treat them more effectively.

The University of South Florida College of Medicine adheres to the ACCME Standards regarding commercial support of continuing medical education. It is the policy of the USF College of Medicine that the faculty and planning committee disclose real or apparent conflicts of interest relating to the topics of this educational activity, that relevant conflict(s) of interest are resolved, and also that speakers will disclose any unlabeled/unapproved use of drug(s) or device(s) during their presentation. Detailed disclosure will be made in the course syllabus.

This program is designed for neurologists and other health care providers that treat patients with neurodegenerative diseases.

Upon the completion of this program, the participant will be able to:

• Describe the mechanisms of neurodegeneration in MS
• Recognize the dual role of inflammation in the brain, damage vs. neuroprotection and develop a plan for care of the MS patient
• Integrate an advanced imaging strategy for monitoring neurodegeneration
• Identify the initial treatment options for PD patients
• Review the basic and clinical research findings about the impact of initial treatment on PD outcomes
• Analyze functional and quality-of-life outcomes in PD

(Outcomes measurement for the objectives will be facilitated using a case-based approach with an Audience Response System).

Physicians: The University of South Florida College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of South Florida designates this educational activity for a maximum of 6.5 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Physician Assistants: AAPA accepts certificates of participation for educational activities certified for Category 1 Credit from AOACCME, Prescribed credit from AAFP, and AMA PRA Category 1 Credits™ from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 6.5 hours of Category 1 Credits for completing this program.

Nurses: The University of South Florida College of Nursing is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation. This activity is for 6.5 contact hours.

7:00 AM – 8:00 AM

7:00 AM – 8:00 AM

Forty 1° NorthExperience seaside cosmopolitan chic at Newport’s newest luxury waterfront venue, Forty 1° North. This venue brings contemporary style and Newport sophistication to every occasion. Forty 1° North blends lavish elegance with functionality to create the quintessential social experience. You will enjoy a cocktail reception and premium open bar in the Windward room where you will marvel at the seaside views. In the adjacent Leeward room a delicious clambake buffet will be set. 6:00 – 9:00 PM

Fees: Adults: $20.00 PP Children (3-11): $10.00 PP Under 3: No charge

Enjoy a Downeast Clambake with a picturesque view. There will be music, food and fun for everyone!

Karl Kieburtz, MD, MPH
Professor, Departments of Neurology and Community & Preventative Medicine
Director, Clinical Trials Coordination Center
University of Rochester School of Medicine and Dentistry
Rochester, NY

Warren Olanow, MD
Chairman and Professor, Neurology
Mount Sinai School of Medicine
New York, NY

Mark Tullman, MD
Assistant Professor of Neurology
Director, Columbia University Multiple Sclerosis
Clinical Care Center
The Neurological Institute of New York
Columbia University Medical Center
New York, NY

Andrew Siderowf, MD, MSCE
Associate Professor of Neurology
University of Pennsylvania School of Medicine
Parkinson’s Disease and Movement Disorders Center
Philadelphia, PA

Daniel Pelletier, MD
Assistant Professor of Neurology
UCSF Multiple Sclerosis Research Center
University of California San Francisco
School of Medicine
San Francisco, CA

The Hotel Viking
One Bellevue Avenue
Newport, RI 02840
Phone 401.848.4800
www.hotelviking.com

Reservations
For Reservations Call: 800.556.7126
Participants attending the “USF: Neuroprotection program” will receive a special
discount room rate of $249. This rate is for the nights of Friday, August 8th and
Saturday, August 9th only. This special rate is for course participants only (one
room per registered participant available at this rate). You must identify yourself as
a course participant when making your room reservation. Rates are subject to all
federal, state and local taxes (currently, Rhode Island state tax is 13%). All guest
rooms are non-smoking. Check-in is after 4:00 PM and check-out is 11:00 AM.

Directions to the Hotel Viking
Situated on fashionable Bellevue Avenue in the historic hill neighborhood, the Hotel
Viking offers guests an intimate haven of comfort and charm. This legendary hotel
is immediately surrounded by fine dining, shopping, and entertainment — all just
minutes from the Newport Harbor waterfront. For your convenience, it is also a
30-minute drive from T.F. Green Airport in Providence.

T.F. Green Airport (27 Miles)
Take I-95 South to Route 4 (Exit 9). Follow Route 4 South, which becomes Route
1 South, to Route 138 East. Cross the Jamestown and Newport bridges. Take the
first exit off Newport Bridge toward Scenic Newport. At the base of the exit, turn
right. Follow to the second light, and turn left. At the stop sign, turn slightly right
onto Thames Street. Follow to the first stoplight, and turn left onto Touro Street.
Follow to the second stoplight. The hotel is on the right-hand side.

For additional directions, go to www.hotelviking.com.

JVC Jazz Festival
While visiting picturesque Newport, why not attend the Jazz Festival!
The 2008 JVC Jazz Festival – Newport will kick off on Friday, August 8th, with an
evening concert at the International Tennis Hall of Fame at the Newport Casino,
followed by two full days of great jazz on three stages at historic Fort Adams State
Park on August 9th and 10th.

Please notify the CPD Office, 12901 Bruce B. Downs Blvd., MDC Box 60, Tampa, Florida, 33612 or call (813) 974-4296 a minimum of ten working days in advance of the event if a reasonable accommodation for a disability is needed.

Events, activities and facilities of the University of South Florida are available without regard to race, color, sex, national origin, disability, age, or Vietnam veteran status as provided by law and in accordance with the University's respect for personal dignity.